以创新表观遗传技术， 守护女性健康

Reply to: Comments on "Enhanced Diagnostic Accuracy of High-Grade Cervical Intraepithelial Neoplasia in Postmenopausal Women Through PAX1/JAM3 Methylation Analysis"

期刊：Int J Cancer

发表单位：Changsha Blood Center

DOI: 10.1002/ijc.70484

宫颈癌分流三型转化区甲基化

Effectiveness analysis and clinical application potential exploration of combined detection of PAX1/JAM3 gene methylation in early diagnosis of cervical precancerous lesions

期刊：Clinical Epigenetics

发表单位：Tumor Hospital Affiliated to Xinjiang Medical University

DOI: 10.1186/s13148-026-02095-z

PAX1/JAM3 methylation-a novel biomarker for early detection and accurate management of cervical adenocarcinoma

期刊：American Journal of Cancer Research

发表单位：解放军联勤保障部队第九四〇医院

DOI: 10.62347/SATU5579

宫颈癌筛查早期发现甲基化

Utility of PAX1/JAM3 methylation analysis for triage of high-risk HPV-positive individuals

期刊：Laboratory Medicine

发表单位：Ziyang Central Hospital

DOI: 10.1093/labmed/lmaf096

Clinical Utility of Cytological Methylation Assay in Cervical Cancer Screening

期刊：Int J Cancer

发表单位：北京协和医院

Diagnostic testing accuracy of DNA methylation tests for detection of high-grade cervical intraepithelial neoplasia and cervical cancer: A systematic review and meta-analysis

期刊：European Journal of Cancer

发表单位：Imperial College London

DOI: 10.1016/j.ejca.2026.116823

PAX1/JAM3双基因联合甲基化检测在宫颈病变管理中的研究进展

期刊：国际妇产科学杂志

发表单位：西北民族大学医学部

DOI: 10.12280/gjfckx.20251474

宫颈脱落细胞基因甲基化检测对宫颈高级别病变术后残留及复发风险的预测意义

期刊：中文科技期刊数据库（引文版）医药卫生

发表单位：桂林市妇幼保健院

Association of PAX1/JAM3 gene methylation, HR-HPV, and TCT with high-grade cervical lesions in a high-risk cohort: a multinomial logistic regression analysis

期刊：BMC women's health

发表单位：First Hospital of Hebei Medical University

DOI: 10.1186/s12905-026-04622-9

Preliminary study on PAX1/JAM3 methylation and HPV viral load in CIN3-like squamous cell carcinoma: Are there differences from CIN3 and early invasive carcinoma?

期刊：Clinical Epigenetics

发表单位：北京大学人民医院

DOI: 10.1186/s13148-026-02201-1

Validation of a cervical CDO1/CELF4 methylation test for endometrial cancer: a prospective paired-sample comparison with intrauterine specimen

期刊：Frontiers in Medicine

发表单位：Gansu Provincial Maternity and Child-care Hospital

DOI: 10.3389/fmed.2026.1690020

Development and validation of hypermethylated gene markers in cervical cytological samples for detecting endometrial cancer (EndoMethy-I trial)

期刊：Frontiers in Oncology

发表单位：Peking Union Medical College Hospital

DOI: 10.3389/fonc.2026.1849730

子宫内膜癌甲基化

Diagnostic Accuracy and Concordance of Self-Collected Cervical CDO1 and CELF4 Methylation Testing Compared With Physician Sampling for Endometrial Cancer Detection

期刊：JCO Precision Oncology

发表单位：The Second Xiangya Hospital of Central South University

DOI: 10.1200/PO-25-01081

Clinical Validation of DNA Methylation Detection in Cervical Exfoliated Cells for Endometrial Cancer in Women with Suspected Lesions

期刊：Diagnostics

发表单位：Obstetrics & Gynecology Hospital of Fudan University

DOI: 10.3390/diagnostics16020174

CDO1 and CELF4 methylation assay as the dominant predictor of endometrial cancer: A cohort analysis across pre- and post-menopausal cohorts

期刊：Gynecologic Oncology

发表单位：Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University)

DOI: 10.1016/j.ygyno.2026.01.776

The triage role of cytological DNA methylation in women with non-16/18, specifically genotyping high-risk HPV infection

期刊：British Journal of Cancer

发表单位：Peking Union Medical College Hospital

DOI: 10.1038/s41416-025-03005-5

Cytologic DNA methylation for managing minimally abnormal cervical cancer screening results

期刊：International Journal of Gynaecology and Obstetrics

发表单位：Peking Union Medical College Hospital

DOI: 10.1002/ijgo.70167

Focused ultrasound ablation for women with cervical lesions: Protocol of a randomized controlled trial

期刊：Reproductive and Developmental Medicine

发表单位：The Third Affiliated Hospital of Zhengzhou University

DOI: 10.1097/RD9.0000000000000132

宫颈癌

The role of PAX1 and JAM3 methylation in predicting the pathological upgrading of cervical intraepithelial neoplasia before conization

期刊：Scientific Reports

发表单位：Zhejiang Provincial People's Hospital

DOI: 10.1038/s41598-025-01422-3

Enhanced diagnostic accuracy of high-grade cervical intraepithelial neoplasia in postmenopausal women through PAX1/JAM3 methylation analysis

期刊：International Journal of Cancer

发表单位：The First Hospital of Hunan University of Chinese Medicine

DOI: 10.1002/ijc.70245

PAX1/JAM3基因甲基化在HR-HPV感染女性中宫颈癌的诊断价值

期刊：标记免疫分析与临床

发表单位：首都医科大学附属北京妇产医院（北京妇幼保健院）

DOI: 10.11748/bjmy.issn.1006-1703.2025.10.008

PAX1/JAM3双基因甲基化在宫颈癌筛查及治疗中的应用

期刊：国际妇产科学杂志

发表单位：山东第一医科大学第二附属医院

DOI: 10.12280/gjfckx.20250484

PAX1、JAM3甲基化对子宫颈高级别上皮内瘤变诊断的meta分析

期刊：现代妇产科进展

发表单位：昆明医科大学附属延安医院

DOI: 10.13283/j.cnki.xdfckjz.2025.09.004

宫颈脱落细胞PAX1、JAM3基因甲基化对宫颈上皮内瘤变预测作用的初步研究

期刊：湖南师范大学学报（医学版）

发表单位：长沙市妇幼保健院

Triage performance of DNA methylation for women with high-risk human papillomavirus infection

期刊：The Oncologist

发表单位：Peking Union Medical College Hospital

DOI: 10.1093/oncolo/oyae324

Prospective Evaluation of Cervical Scrapings CDO1 and CELF4 Methylation (epiHERA?) Assay in Detection of Endometrial Cancer

期刊：Cancers

发表单位：The Chinese University of Hong Kong

DOI: 10.3390/cancers17183010

The performance of JAM3/PAX1 methylation in the diagnosis of high-grade squamous intraepithelial lesions for women with high-risk HPV infection

期刊：BMC cancer

发表单位：the Third Xiangya Hospital of Central South University

DOI: 10.1186/s12885-024-13299-y

PAX1/JAM3 Methylation and HPV Viral Load in Women with Persistent HPV Infection

期刊：Cancers

发表单位：Peking University People's Hospital

DOI: 10.3390/cancers16071430

阴道微生态影响宫颈细胞DNA甲基化水平与宫颈病变的相关性研究

期刊：中华检验医学杂志

发表单位：中南大学湘雅三医院

女性阴道自采样本检测PAX1/JAM3双基因甲基化标志物作为子宫颈癌筛查的可行性评估

期刊：中华检验医学杂志

发表单位：南华大学附属第一医院

DOI: 10.3760/cma.j.cn114452-20240109-00016

JAM3基因DNA甲基化在宫颈高级别上皮内瘤变及术后复发预测的临床研究

期刊：临床医学进展 (Advances in Clinical Medicine)

发表单位：临沂市中心医院

DOI: 10.12677/acm.2024.1472146

[A multicenter study on the accuracy of PAX1/JAM3 dual genes methylation testing for screening cervical cancer]

期刊：Zhonghua Yi Xue Za Zhi

发表单位：Peking Union Medical College Hospital

DOI: 10.3760/cma.j.cn12137-20231004-00630

Triage performance of PAX1m/JAM3m in opportunistic cervical cancer screening of non?16/18 human papillomavirus-positive women: a multicenter prospective study in China

期刊：Clinical Epigenetics

发表单位：Peking Union Medical College Hospital

DOI: 10.1186/s13148-024-01731-w

Cervical cancer screening: efficacy of PAX1 and JAM3 methylation assay in the triage of atypical squamous cell of undetermined significance (ASC-US)

期刊：BMC cancer

发表单位：Zhejiang Provincial People's Hospital

DOI: 10.1186/s12885-024-13082-z

Assessment of PAX1 and JAM3 methylation triage efficacy across HPV genotypes and age groups in high-risk HPV-positive women in China

期刊：Frontiers in Oncology

发表单位：Xuzhou Maternity and Child Health Hospital

DOI: 10.3389/fonc.2024.1481626

Evaluating PAX1/JAM3 methylation for triage in HPV 16/18-infected women

期刊：Clinical Epigenetics

发表单位：The Second Affiliated Hospital, Zhejiang University School of Medicine

DOI: 10.1186/s13148-024-01804-w

The endometrial cancer detection using non-invasive hypermethylation of CDO1 and CELF4 genes in women with postmenopausal bleeding in Northwest China

期刊：CytoJournal

发表单位：Gansu Provincial Maternity and Child-care Hospital

DOI: 10.25259/Cytojournal_78_2023

子宫内膜癌筛查分流甲基化

DNA methylation detection is a significant biomarker for screening endometrial cancer in premenopausal women with abnormal uterine bleeding

期刊：International Journal of Gynecological Cancer: Official Journal of the International Gynecological Cancer Society

发表单位：the Third Xiangya Hospital, Central South University

DOI: 10.1136/ijgc-2024-005723

禾蔻安双基因甲基化检测在子宫内膜癌筛查中的应用价值

期刊：兰州大学学报（医学版）

发表单位：Gansu Maternal and Child Health Hospital

DOI: 10.13885/j.issn.1000-2812.2024.07.004

血清中CDO1基因与HOXA9基因启动子甲基化高表达在卵巢癌诊断中的意义

期刊：中华检验医学杂志

发表单位：成都市妇女儿童中心医院

DOI: 10.3760/cma.j.cn114452-20231115-00287

卵巢癌甲基化

High-grade cervical lesions diagnosed by JAM3/PAX1 methylation in high-risk human papillomavirus-infected patients

期刊：Journal of Central South University (Medical Sciences)

发表单位：中南大学湘雅三医院

DOI: 10.11817/j.issn.1672-7347.2023.230175

DNA甲基化检测在绝经后女性子宫内膜癌筛查中的应用价值

期刊：中华医学杂志

发表单位：北京协和医院

DOI: 10.3760/cma.j.cn114452-20221110-00670

子宫内膜癌筛查早期发现甲基化

DNA甲基化检测在育龄期异常子宫出血女性子宫内膜癌诊断中的应用价值

期刊：中华检验医学杂志

发表单位：中南大学湘雅三医院

Hypermethylated CDO1 and CELF4 in cytological specimens as triage strategy biomarkers in endometrial malignant lesions.

期刊：Frontiers in oncology

发表单位：Cangzhou Central Hospital

DOI: 10.3389/fonc.2023.1289366

PAX1/JAM3 methylation in cervical exfoliated cells: a robust diagnostic biomarker for cervical high-grade lesions associated with vaginal dysbiosis

期刊：BMC Women's Health

发表单位：Beijing Anzhen Hospital

DOI: 10.1186/s12905-026-04285-6

Reply to: Comments on "Enhanced Diagnostic Accuracy of High-Grade Cervical Intraepithelial Neoplasia in Postmenopausal Women Through PAX1/JAM3 Methylation Analysis"

期刊：Int J Cancer

发表单位：Changsha Blood Center

DOI: 10.1002/ijc.70484

宫颈癌分流三型转化区甲基化

Effectiveness analysis and clinical application potential exploration of combined detection of PAX1/JAM3 gene methylation in early diagnosis of cervical precancerous lesions

期刊：Clinical Epigenetics

发表单位：Tumor Hospital Affiliated to Xinjiang Medical University

DOI: 10.1186/s13148-026-02095-z

PAX1/JAM3 methylation-a novel biomarker for early detection and accurate management of cervical adenocarcinoma

期刊：American Journal of Cancer Research

发表单位：解放军联勤保障部队第九四〇医院

DOI: 10.62347/SATU5579

宫颈癌筛查早期发现甲基化

Utility of PAX1/JAM3 methylation analysis for triage of high-risk HPV-positive individuals

期刊：Laboratory Medicine

发表单位：Ziyang Central Hospital

DOI: 10.1093/labmed/lmaf096

Clinical Utility of Cytological Methylation Assay in Cervical Cancer Screening

期刊：Int J Cancer

发表单位：北京协和医院

Diagnostic testing accuracy of DNA methylation tests for detection of high-grade cervical intraepithelial neoplasia and cervical cancer: A systematic review and meta-analysis

期刊：European Journal of Cancer

发表单位：Imperial College London

DOI: 10.1016/j.ejca.2026.116823

PAX1/JAM3双基因联合甲基化检测在宫颈病变管理中的研究进展

期刊：国际妇产科学杂志

发表单位：西北民族大学医学部

DOI: 10.12280/gjfckx.20251474

宫颈脱落细胞基因甲基化检测对宫颈高级别病变术后残留及复发风险的预测意义

期刊：中文科技期刊数据库（引文版）医药卫生

发表单位：桂林市妇幼保健院

Association of PAX1/JAM3 gene methylation, HR-HPV, and TCT with high-grade cervical lesions in a high-risk cohort: a multinomial logistic regression analysis

期刊：BMC women's health

发表单位：First Hospital of Hebei Medical University

DOI: 10.1186/s12905-026-04622-9

Preliminary study on PAX1/JAM3 methylation and HPV viral load in CIN3-like squamous cell carcinoma: Are there differences from CIN3 and early invasive carcinoma?

期刊：Clinical Epigenetics

发表单位：北京大学人民医院

DOI: 10.1186/s13148-026-02201-1

Validation of a cervical CDO1/CELF4 methylation test for endometrial cancer: a prospective paired-sample comparison with intrauterine specimen

期刊：Frontiers in Medicine

发表单位：Gansu Provincial Maternity and Child-care Hospital

DOI: 10.3389/fmed.2026.1690020

Development and validation of hypermethylated gene markers in cervical cytological samples for detecting endometrial cancer (EndoMethy-I trial)

期刊：Frontiers in Oncology

发表单位：Peking Union Medical College Hospital

DOI: 10.3389/fonc.2026.1849730

子宫内膜癌甲基化

Diagnostic Accuracy and Concordance of Self-Collected Cervical CDO1 and CELF4 Methylation Testing Compared With Physician Sampling for Endometrial Cancer Detection

期刊：JCO Precision Oncology

发表单位：The Second Xiangya Hospital of Central South University

DOI: 10.1200/PO-25-01081

Clinical Validation of DNA Methylation Detection in Cervical Exfoliated Cells for Endometrial Cancer in Women with Suspected Lesions

期刊：Diagnostics

发表单位：Obstetrics & Gynecology Hospital of Fudan University

DOI: 10.3390/diagnostics16020174

CDO1 and CELF4 methylation assay as the dominant predictor of endometrial cancer: A cohort analysis across pre- and post-menopausal cohorts

期刊：Gynecologic Oncology

发表单位：Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University)

DOI: 10.1016/j.ygyno.2026.01.776

The triage role of cytological DNA methylation in women with non-16/18, specifically genotyping high-risk HPV infection

期刊：British Journal of Cancer

发表单位：Peking Union Medical College Hospital

DOI: 10.1038/s41416-025-03005-5

Cytologic DNA methylation for managing minimally abnormal cervical cancer screening results

期刊：International Journal of Gynaecology and Obstetrics

发表单位：Peking Union Medical College Hospital

DOI: 10.1002/ijgo.70167

Focused ultrasound ablation for women with cervical lesions: Protocol of a randomized controlled trial

期刊：Reproductive and Developmental Medicine

发表单位：The Third Affiliated Hospital of Zhengzhou University

DOI: 10.1097/RD9.0000000000000132

宫颈癌

The role of PAX1 and JAM3 methylation in predicting the pathological upgrading of cervical intraepithelial neoplasia before conization

期刊：Scientific Reports

发表单位：Zhejiang Provincial People's Hospital

DOI: 10.1038/s41598-025-01422-3

Enhanced diagnostic accuracy of high-grade cervical intraepithelial neoplasia in postmenopausal women through PAX1/JAM3 methylation analysis

期刊：International Journal of Cancer

发表单位：The First Hospital of Hunan University of Chinese Medicine

DOI: 10.1002/ijc.70245

PAX1/JAM3基因甲基化在HR-HPV感染女性中宫颈癌的诊断价值

期刊：标记免疫分析与临床

发表单位：首都医科大学附属北京妇产医院（北京妇幼保健院）

DOI: 10.11748/bjmy.issn.1006-1703.2025.10.008

PAX1/JAM3双基因甲基化在宫颈癌筛查及治疗中的应用

期刊：国际妇产科学杂志

发表单位：山东第一医科大学第二附属医院

DOI: 10.12280/gjfckx.20250484

PAX1、JAM3甲基化对子宫颈高级别上皮内瘤变诊断的meta分析

期刊：现代妇产科进展

发表单位：昆明医科大学附属延安医院

DOI: 10.13283/j.cnki.xdfckjz.2025.09.004

宫颈脱落细胞PAX1、JAM3基因甲基化对宫颈上皮内瘤变预测作用的初步研究

期刊：湖南师范大学学报（医学版）

发表单位：长沙市妇幼保健院

Triage performance of DNA methylation for women with high-risk human papillomavirus infection

期刊：The Oncologist

发表单位：Peking Union Medical College Hospital

DOI: 10.1093/oncolo/oyae324

Prospective Evaluation of Cervical Scrapings CDO1 and CELF4 Methylation (epiHERA?) Assay in Detection of Endometrial Cancer

期刊：Cancers

发表单位：The Chinese University of Hong Kong

DOI: 10.3390/cancers17183010

The performance of JAM3/PAX1 methylation in the diagnosis of high-grade squamous intraepithelial lesions for women with high-risk HPV infection

期刊：BMC cancer

发表单位：the Third Xiangya Hospital of Central South University

DOI: 10.1186/s12885-024-13299-y

PAX1/JAM3 Methylation and HPV Viral Load in Women with Persistent HPV Infection

期刊：Cancers

发表单位：Peking University People's Hospital

DOI: 10.3390/cancers16071430

阴道微生态影响宫颈细胞DNA甲基化水平与宫颈病变的相关性研究

期刊：中华检验医学杂志

发表单位：中南大学湘雅三医院

女性阴道自采样本检测PAX1/JAM3双基因甲基化标志物作为子宫颈癌筛查的可行性评估

期刊：中华检验医学杂志

发表单位：南华大学附属第一医院

DOI: 10.3760/cma.j.cn114452-20240109-00016

JAM3基因DNA甲基化在宫颈高级别上皮内瘤变及术后复发预测的临床研究

期刊：临床医学进展 (Advances in Clinical Medicine)

发表单位：临沂市中心医院

DOI: 10.12677/acm.2024.1472146

[A multicenter study on the accuracy of PAX1/JAM3 dual genes methylation testing for screening cervical cancer]

期刊：Zhonghua Yi Xue Za Zhi

发表单位：Peking Union Medical College Hospital

DOI: 10.3760/cma.j.cn12137-20231004-00630

Triage performance of PAX1m/JAM3m in opportunistic cervical cancer screening of non?16/18 human papillomavirus-positive women: a multicenter prospective study in China

期刊：Clinical Epigenetics

发表单位：Peking Union Medical College Hospital

DOI: 10.1186/s13148-024-01731-w

Cervical cancer screening: efficacy of PAX1 and JAM3 methylation assay in the triage of atypical squamous cell of undetermined significance (ASC-US)

期刊：BMC cancer

发表单位：Zhejiang Provincial People's Hospital

DOI: 10.1186/s12885-024-13082-z

Assessment of PAX1 and JAM3 methylation triage efficacy across HPV genotypes and age groups in high-risk HPV-positive women in China

期刊：Frontiers in Oncology

发表单位：Xuzhou Maternity and Child Health Hospital

DOI: 10.3389/fonc.2024.1481626

Evaluating PAX1/JAM3 methylation for triage in HPV 16/18-infected women

期刊：Clinical Epigenetics

发表单位：The Second Affiliated Hospital, Zhejiang University School of Medicine

DOI: 10.1186/s13148-024-01804-w

The endometrial cancer detection using non-invasive hypermethylation of CDO1 and CELF4 genes in women with postmenopausal bleeding in Northwest China

期刊：CytoJournal

发表单位：Gansu Provincial Maternity and Child-care Hospital

DOI: 10.25259/Cytojournal_78_2023

子宫内膜癌筛查分流甲基化

DNA methylation detection is a significant biomarker for screening endometrial cancer in premenopausal women with abnormal uterine bleeding

期刊：International Journal of Gynecological Cancer: Official Journal of the International Gynecological Cancer Society

发表单位：the Third Xiangya Hospital, Central South University

DOI: 10.1136/ijgc-2024-005723

禾蔻安双基因甲基化检测在子宫内膜癌筛查中的应用价值

期刊：兰州大学学报（医学版）

发表单位：Gansu Maternal and Child Health Hospital

DOI: 10.13885/j.issn.1000-2812.2024.07.004

血清中CDO1基因与HOXA9基因启动子甲基化高表达在卵巢癌诊断中的意义

期刊：中华检验医学杂志

发表单位：成都市妇女儿童中心医院

DOI: 10.3760/cma.j.cn114452-20231115-00287

卵巢癌甲基化

High-grade cervical lesions diagnosed by JAM3/PAX1 methylation in high-risk human papillomavirus-infected patients

期刊：Journal of Central South University (Medical Sciences)

发表单位：中南大学湘雅三医院

DOI: 10.11817/j.issn.1672-7347.2023.230175

DNA甲基化检测在绝经后女性子宫内膜癌筛查中的应用价值

期刊：中华医学杂志

发表单位：北京协和医院

DOI: 10.3760/cma.j.cn114452-20221110-00670

子宫内膜癌筛查早期发现甲基化

DNA甲基化检测在育龄期异常子宫出血女性子宫内膜癌诊断中的应用价值

期刊：中华检验医学杂志

发表单位：中南大学湘雅三医院

Hypermethylated CDO1 and CELF4 in cytological specimens as triage strategy biomarkers in endometrial malignant lesions.

期刊：Frontiers in oncology

发表单位：Cangzhou Central Hospital

DOI: 10.3389/fonc.2023.1289366

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子宫内膜癌基因甲基化筛查技术临床应用专家共识（2026版）

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DOI: 10.3760/cma.j.cn112137-20260301-00576

欧洲妇科肿瘤学会/欧洲妇科倡导团体网络关于基于风险的宫颈癌筛查立场声明

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