CISCER®
Dual-gene methylation test, empowering cervical cancer prevention
PAX1/JAM3 dual-gene combined test using non-invasive cervical exfoliated cell sampling, accurately identifying CIN2+ high-grade lesions for precise triage.
Robust clinical data support
Based on multi-center registered clinical trials, sensitivity and specificity both reach industry-leading levels.
Who needs this test?
- Precision triage for HPV-positive individuals
- Women with mild cytological abnormalities (ASC-US)
- Cervical cancer screening for postmenopausal women
- Treatment response and recurrence monitoring for cervical lesions
How is it applied clinically?
- Opportunistic and population-based cervical cancer screening
- Colposcopy referral decisions after HPV-positive results
- Post-treatment follow-up for high-grade cervical lesions
- Women's health dual-screening programs at health checkup centers
Why choose us
Dual-gene (PAX1/JAM3) combined test with superior performance
Supported by multi-center study data with 10,000+ paired cases
Recommended by multiple domestic and international expert consensus and guidelines
Ongoing nationwide multi-center real-world studies
Cervical Cancer Related Publications
Reply to: Comments on "Enhanced Diagnostic Accuracy of High-Grade Cervical Intraepithelial Neoplasia in Postmenopausal Women Through PAX1/JAM3 Methylation Analysis"
Journal: International Journal of Cancer
Affiliation: Changsha Blood Center
DOI: 10.1002/ijc.70484
Effectiveness analysis and clinical application potential exploration of combined detection of PAX1/JAM3 gene methylation in early diagnosis of cervical precancerous lesions
Journal: Clinical Epigenetics
Affiliation: Tumor Hospital Affiliated to Xinjiang Medical University
DOI: 10.1186/s13148-026-02095-z
PAX1/JAM3 methylation - a novel biomarker for early detection and accurate management of cervical adenocarcinoma
Journal: American Journal of Cancer Research
Affiliation: The 940th Hospital of Joint Logistics Support Force of PLA
DOI: 10.62347/SATU5579
Diagnostic testing accuracy of DNA methylation tests for detection of high-grade cervical intraepithelial neoplasia and cervical cancer: A systematic review and meta-analysis
Journal: European Journal of Cancer
Affiliation: Imperial College London
DOI: 10.1016/j.ejca.2026.116823
Association of PAX1/JAM3 gene methylation, HR-HPV, and TCT with high-grade cervical lesions in a high-risk cohort: a multinomial logistic regression analysis
Journal: BMC Women's Health
Affiliation: First Hospital of Hebei Medical University
DOI: 10.1186/s12905-026-04622-9
Preliminary study on PAX1/JAM3 methylation and HPV viral load in CIN3-like squamous cell carcinoma: Are there differences from CIN3 and early invasive carcinoma?
Journal: Clinical Epigenetics
Affiliation: Peking University People's Hospital
DOI: 10.1186/s13148-026-02201-1
Enhanced diagnostic accuracy of high-grade cervical intraepithelial neoplasia in postmenopausal women through PAX1/JAM3 methylation analysis
Journal: International Journal of Cancer
Affiliation: The First Hospital of Hunan University of Chinese Medicine
DOI: 10.1002/ijc.70245
Diagnostic value of PAX1/JAM3 gene methylation for cervical cancer in HR-HPV-infected women
Journal: Labeled Immunoassays and Clinical Medicine
Affiliation: Beijing Obstetrics and Gynecology Hospital, Capital Medical University (Beijing Maternal and Child Health Care Hospital)
DOI: 10.11748/bjmy.issn.1006-1703.2025.10.008
Application of PAX1/JAM3 dual-gene methylation in cervical cancer screening and treatment
Journal: International Journal of Obstetrics and Gynecology
Affiliation: The Second Affiliated Hospital of Shandong First Medical University
DOI: 10.12280/gjfckx.20250484
Preliminary study on the predictive value of PAX1 and JAM3 gene methylation in cervical exfoliated cells for cervical intraepithelial neoplasia
Journal: Journal of Hunan Normal University (Medical Sciences)
Affiliation: Changsha Maternal and Child Health Hospital
The performance of JAM3/PAX1 methylation in the diagnosis of high-grade squamous intraepithelial lesions for women with high-risk HPV infection
Journal: BMC cancer
Affiliation: The Third Xiangya Hospital of Central South University
DOI: 10.1186/s12885-024-13299-y
Triage performance of PAX1m/JAM3m in opportunistic cervical cancer screening of non-16/18 human papillomavirus-positive women: a multicenter prospective study
Journal: Clinical Epigenetics
Affiliation: Peking Union Medical College Hospital
DOI: 10.1186/s13148-024-01731-w
High-grade cervical lesions diagnosed by JAM3/PAX1 methylation in high-risk human papillomavirus-infected patients
Journal: Journal of Central South University (Medical Sciences)
Affiliation: The Third Xiangya Hospital of Central South University
DOI: 10.11817/j.issn.1672-7347.2023.230175
Reply to: Comments on "Enhanced Diagnostic Accuracy of High-Grade Cervical Intraepithelial Neoplasia in Postmenopausal Women Through PAX1/JAM3 Methylation Analysis"
Journal: International Journal of Cancer
Affiliation: Changsha Blood Center
DOI: 10.1002/ijc.70484
Effectiveness analysis and clinical application potential exploration of combined detection of PAX1/JAM3 gene methylation in early diagnosis of cervical precancerous lesions
Journal: Clinical Epigenetics
Affiliation: Tumor Hospital Affiliated to Xinjiang Medical University
DOI: 10.1186/s13148-026-02095-z
PAX1/JAM3 methylation - a novel biomarker for early detection and accurate management of cervical adenocarcinoma
Journal: American Journal of Cancer Research
Affiliation: The 940th Hospital of Joint Logistics Support Force of PLA
DOI: 10.62347/SATU5579
Diagnostic testing accuracy of DNA methylation tests for detection of high-grade cervical intraepithelial neoplasia and cervical cancer: A systematic review and meta-analysis
Journal: European Journal of Cancer
Affiliation: Imperial College London
DOI: 10.1016/j.ejca.2026.116823
Association of PAX1/JAM3 gene methylation, HR-HPV, and TCT with high-grade cervical lesions in a high-risk cohort: a multinomial logistic regression analysis
Journal: BMC Women's Health
Affiliation: First Hospital of Hebei Medical University
DOI: 10.1186/s12905-026-04622-9
Preliminary study on PAX1/JAM3 methylation and HPV viral load in CIN3-like squamous cell carcinoma: Are there differences from CIN3 and early invasive carcinoma?
Journal: Clinical Epigenetics
Affiliation: Peking University People's Hospital
DOI: 10.1186/s13148-026-02201-1
Enhanced diagnostic accuracy of high-grade cervical intraepithelial neoplasia in postmenopausal women through PAX1/JAM3 methylation analysis
Journal: International Journal of Cancer
Affiliation: The First Hospital of Hunan University of Chinese Medicine
DOI: 10.1002/ijc.70245
Diagnostic value of PAX1/JAM3 gene methylation for cervical cancer in HR-HPV-infected women
Journal: Labeled Immunoassays and Clinical Medicine
Affiliation: Beijing Obstetrics and Gynecology Hospital, Capital Medical University (Beijing Maternal and Child Health Care Hospital)
DOI: 10.11748/bjmy.issn.1006-1703.2025.10.008
Application of PAX1/JAM3 dual-gene methylation in cervical cancer screening and treatment
Journal: International Journal of Obstetrics and Gynecology
Affiliation: The Second Affiliated Hospital of Shandong First Medical University
DOI: 10.12280/gjfckx.20250484
Preliminary study on the predictive value of PAX1 and JAM3 gene methylation in cervical exfoliated cells for cervical intraepithelial neoplasia
Journal: Journal of Hunan Normal University (Medical Sciences)
Affiliation: Changsha Maternal and Child Health Hospital
The performance of JAM3/PAX1 methylation in the diagnosis of high-grade squamous intraepithelial lesions for women with high-risk HPV infection
Journal: BMC cancer
Affiliation: The Third Xiangya Hospital of Central South University
DOI: 10.1186/s12885-024-13299-y
Triage performance of PAX1m/JAM3m in opportunistic cervical cancer screening of non-16/18 human papillomavirus-positive women: a multicenter prospective study
Journal: Clinical Epigenetics
Affiliation: Peking Union Medical College Hospital
DOI: 10.1186/s13148-024-01731-w
High-grade cervical lesions diagnosed by JAM3/PAX1 methylation in high-risk human papillomavirus-infected patients
Journal: Journal of Central South University (Medical Sciences)
Affiliation: The Third Xiangya Hospital of Central South University
DOI: 10.11817/j.issn.1672-7347.2023.230175
