Guarding women’s health with
innovative epigenetic technology
CISPOLY focuses on DNA methylation-based early screening and diagnosis of cervical, endometrial, and ovarian cancers, filling clinical gaps with non-invasive technology to benefit women in China and worldwide.
Accurate, leaving no lesion hidden
Accessible, bringing screening within reach
Non-invasive, giving women peace of mind
Making gynecologic cancer early screening accessible to every woman through methylation innovation.
Three core products covering all three major gynecologic cancers
DNA methylation-based non-invasive early screening and diagnostic products for cervical, endometrial, and ovarian cancers.
Building professional trust through evidence-based data
Evidence-based, continuously innovating
Conducting multiple prospective multi-center clinical trials with numerous publications, advancing methylation applications through evidence.
Reply to: Comments on "Enhanced Diagnostic Accuracy of High-Grade Cervical Intraepithelial Neoplasia in Postmenopausal Women Through PAX1/JAM3 Methylation Analysis"
Journal: International Journal of Cancer
Affiliation: Changsha Blood Center
DOI: 10.1002/ijc.70484
Effectiveness analysis and clinical application potential exploration of combined detection of PAX1/JAM3 gene methylation in early diagnosis of cervical precancerous lesions
Journal: Clinical Epigenetics
Affiliation: Tumor Hospital Affiliated to Xinjiang Medical University
DOI: 10.1186/s13148-026-02095-z
PAX1/JAM3 methylation - a novel biomarker for early detection and accurate management of cervical adenocarcinoma
Journal: American Journal of Cancer Research
Affiliation: The 940th Hospital of Joint Logistics Support Force of PLA
DOI: 10.62347/SATU5579
Diagnostic testing accuracy of DNA methylation tests for detection of high-grade cervical intraepithelial neoplasia and cervical cancer: A systematic review and meta-analysis
Journal: European Journal of Cancer
Affiliation: Imperial College London
DOI: 10.1016/j.ejca.2026.116823
Association of PAX1/JAM3 gene methylation, HR-HPV, and TCT with high-grade cervical lesions in a high-risk cohort: a multinomial logistic regression analysis
Journal: BMC Women's Health
Affiliation: First Hospital of Hebei Medical University
DOI: 10.1186/s12905-026-04622-9
Preliminary study on PAX1/JAM3 methylation and HPV viral load in CIN3-like squamous cell carcinoma: Are there differences from CIN3 and early invasive carcinoma?
Journal: Clinical Epigenetics
Affiliation: Peking University People's Hospital
DOI: 10.1186/s13148-026-02201-1
Validation of a cervical CDO1/CELF4 methylation test for endometrial cancer: a prospective paired-sample comparison with intrauterine specimens
Journal: Frontiers in Medicine
Affiliation: Gansu Provincial Maternity and Child-care Hospital
DOI: 10.3389/fmed.2026.1690020
Diagnostic Accuracy and Concordance of Self-Collected Cervical CDO1 and CELF4 Methylation Testing Compared With Physician Sampling for Endometrial Cancer
Journal: JCO Precision Oncology
Affiliation: The Second Xiangya Hospital of Central South University
DOI: 10.1200/PO-25-01081
CDO1 and CELF4 methylation assay as the dominant predictor of endometrial cancer: A cohort analysis across pre- and post-menopausal cohorts
Journal: Gynecologic Oncology
Affiliation: Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University)
DOI: 10.1016/j.ygyno.2026.01.776
Enhanced diagnostic accuracy of high-grade cervical intraepithelial neoplasia in postmenopausal women through PAX1/JAM3 methylation analysis
Journal: International Journal of Cancer
Affiliation: The First Hospital of Hunan University of Chinese Medicine
DOI: 10.1002/ijc.70245
Diagnostic value of PAX1/JAM3 gene methylation for cervical cancer in HR-HPV-infected women
Journal: Labeled Immunoassays and Clinical Medicine
Affiliation: Beijing Obstetrics and Gynecology Hospital, Capital Medical University (Beijing Maternal and Child Health Care Hospital)
DOI: 10.11748/bjmy.issn.1006-1703.2025.10.008
Application of PAX1/JAM3 dual-gene methylation in cervical cancer screening and treatment
Journal: International Journal of Obstetrics and Gynecology
Affiliation: The Second Affiliated Hospital of Shandong First Medical University
DOI: 10.12280/gjfckx.20250484
Preliminary study on the predictive value of PAX1 and JAM3 gene methylation in cervical exfoliated cells for cervical intraepithelial neoplasia
Journal: Journal of Hunan Normal University (Medical Sciences)
Affiliation: Changsha Maternal and Child Health Hospital
The performance of JAM3/PAX1 methylation in the diagnosis of high-grade squamous intraepithelial lesions for women with high-risk HPV infection
Journal: BMC cancer
Affiliation: The Third Xiangya Hospital of Central South University
DOI: 10.1186/s12885-024-13299-y
Triage performance of PAX1m/JAM3m in opportunistic cervical cancer screening of non-16/18 human papillomavirus-positive women: a multicenter prospective study
Journal: Clinical Epigenetics
Affiliation: Peking Union Medical College Hospital
DOI: 10.1186/s13148-024-01731-w
The endometrial cancer detection using non-invasive hypermethylation of CDO1 and CELF4 genes in women with postmenopausal bleeding in Northwest China
Journal: CytoJournal
Affiliation: Gansu Provincial Maternity and Child-care Hospital
DOI: 10.25259/Cytojournal_78_2023
DNA methylation detection is a significant biomarker for screening endometrial cancer in premenopausal women with abnormal uterine bleeding
Journal: International Journal of Gynecological Cancer
Affiliation: The Third Xiangya Hospital, Central South University
DOI: 10.1136/ijgc-2024-005723
High-grade cervical lesions diagnosed by JAM3/PAX1 methylation in high-risk human papillomavirus-infected patients
Journal: Journal of Central South University (Medical Sciences)
Affiliation: The Third Xiangya Hospital of Central South University
DOI: 10.11817/j.issn.1672-7347.2023.230175
Reply to: Comments on "Enhanced Diagnostic Accuracy of High-Grade Cervical Intraepithelial Neoplasia in Postmenopausal Women Through PAX1/JAM3 Methylation Analysis"
Journal: International Journal of Cancer
Affiliation: Changsha Blood Center
DOI: 10.1002/ijc.70484
Effectiveness analysis and clinical application potential exploration of combined detection of PAX1/JAM3 gene methylation in early diagnosis of cervical precancerous lesions
Journal: Clinical Epigenetics
Affiliation: Tumor Hospital Affiliated to Xinjiang Medical University
DOI: 10.1186/s13148-026-02095-z
PAX1/JAM3 methylation - a novel biomarker for early detection and accurate management of cervical adenocarcinoma
Journal: American Journal of Cancer Research
Affiliation: The 940th Hospital of Joint Logistics Support Force of PLA
DOI: 10.62347/SATU5579
Diagnostic testing accuracy of DNA methylation tests for detection of high-grade cervical intraepithelial neoplasia and cervical cancer: A systematic review and meta-analysis
Journal: European Journal of Cancer
Affiliation: Imperial College London
DOI: 10.1016/j.ejca.2026.116823
Association of PAX1/JAM3 gene methylation, HR-HPV, and TCT with high-grade cervical lesions in a high-risk cohort: a multinomial logistic regression analysis
Journal: BMC Women's Health
Affiliation: First Hospital of Hebei Medical University
DOI: 10.1186/s12905-026-04622-9
Preliminary study on PAX1/JAM3 methylation and HPV viral load in CIN3-like squamous cell carcinoma: Are there differences from CIN3 and early invasive carcinoma?
Journal: Clinical Epigenetics
Affiliation: Peking University People's Hospital
DOI: 10.1186/s13148-026-02201-1
Validation of a cervical CDO1/CELF4 methylation test for endometrial cancer: a prospective paired-sample comparison with intrauterine specimens
Journal: Frontiers in Medicine
Affiliation: Gansu Provincial Maternity and Child-care Hospital
DOI: 10.3389/fmed.2026.1690020
Diagnostic Accuracy and Concordance of Self-Collected Cervical CDO1 and CELF4 Methylation Testing Compared With Physician Sampling for Endometrial Cancer
Journal: JCO Precision Oncology
Affiliation: The Second Xiangya Hospital of Central South University
DOI: 10.1200/PO-25-01081
CDO1 and CELF4 methylation assay as the dominant predictor of endometrial cancer: A cohort analysis across pre- and post-menopausal cohorts
Journal: Gynecologic Oncology
Affiliation: Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University)
DOI: 10.1016/j.ygyno.2026.01.776
Enhanced diagnostic accuracy of high-grade cervical intraepithelial neoplasia in postmenopausal women through PAX1/JAM3 methylation analysis
Journal: International Journal of Cancer
Affiliation: The First Hospital of Hunan University of Chinese Medicine
DOI: 10.1002/ijc.70245
Diagnostic value of PAX1/JAM3 gene methylation for cervical cancer in HR-HPV-infected women
Journal: Labeled Immunoassays and Clinical Medicine
Affiliation: Beijing Obstetrics and Gynecology Hospital, Capital Medical University (Beijing Maternal and Child Health Care Hospital)
DOI: 10.11748/bjmy.issn.1006-1703.2025.10.008
Application of PAX1/JAM3 dual-gene methylation in cervical cancer screening and treatment
Journal: International Journal of Obstetrics and Gynecology
Affiliation: The Second Affiliated Hospital of Shandong First Medical University
DOI: 10.12280/gjfckx.20250484
Preliminary study on the predictive value of PAX1 and JAM3 gene methylation in cervical exfoliated cells for cervical intraepithelial neoplasia
Journal: Journal of Hunan Normal University (Medical Sciences)
Affiliation: Changsha Maternal and Child Health Hospital
The performance of JAM3/PAX1 methylation in the diagnosis of high-grade squamous intraepithelial lesions for women with high-risk HPV infection
Journal: BMC cancer
Affiliation: The Third Xiangya Hospital of Central South University
DOI: 10.1186/s12885-024-13299-y
Triage performance of PAX1m/JAM3m in opportunistic cervical cancer screening of non-16/18 human papillomavirus-positive women: a multicenter prospective study
Journal: Clinical Epigenetics
Affiliation: Peking Union Medical College Hospital
DOI: 10.1186/s13148-024-01731-w
The endometrial cancer detection using non-invasive hypermethylation of CDO1 and CELF4 genes in women with postmenopausal bleeding in Northwest China
Journal: CytoJournal
Affiliation: Gansu Provincial Maternity and Child-care Hospital
DOI: 10.25259/Cytojournal_78_2023
DNA methylation detection is a significant biomarker for screening endometrial cancer in premenopausal women with abnormal uterine bleeding
Journal: International Journal of Gynecological Cancer
Affiliation: The Third Xiangya Hospital, Central South University
DOI: 10.1136/ijgc-2024-005723
High-grade cervical lesions diagnosed by JAM3/PAX1 methylation in high-risk human papillomavirus-infected patients
Journal: Journal of Central South University (Medical Sciences)
Affiliation: The Third Xiangya Hospital of Central South University
DOI: 10.11817/j.issn.1672-7347.2023.230175
Recommended by multiple guidelines and consensus
Multiple national clinical guidelines and expert consensus statements support the standardized clinical application of our products.
CISPOLY Updates
Research achievements, guideline consensus, conference highlights, and health education — continuously updated.
